Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
Home | Login
About PhosphoSiteUsing PhosphoSiteprivacy & cookiesCuration ProcessContact
logos LINCs Logo Mt Sinai Logo NIH Logo NCI Logo
Search / Browse Functions
Protein Page:
TCF12 iso3

TCF12 iso3 Binds specifically to oligomers of E-box motifs. May play important roles during development of the nervous system as well as in other organ systems. Efficient DNA binding requires dimerization with another bHLH protein. Forms homo- or hetero-oligomers with myogenin, E12 and ITF2 proteins. Interacts with PTF1A. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Transcription factor
Chromosomal Location of Human Ortholog: 15q21.3
Cellular Component: cytoplasm; intracellular membrane-bound organelle; nuclear chromatin; nuclear speck; nucleoplasm; nucleus
Molecular Function: bHLH transcription factor binding; protein binding; protein heterodimerization activity; protein homodimerization activity; SMAD binding; transcription factor activity; transcription factor binding
Biological Process: immune response; muscle development; positive regulation of neuron differentiation; positive regulation of transcription from RNA polymerase II promoter; regulation of transcription from RNA polymerase II promoter
Reference #:  Q99081-3 (UniProtKB)
Alt. Names/Synonyms: BHLHB20; Class B basic helix-loop-helix protein 20; DNA-binding protein HTF4; E-box-binding protein; HEB; helix-loop-helix transcription factor 4; HsT17266; HTF4; TCF-12; TCF12; Transcription factor 12; Transcription factor HTF-4
Gene Symbols: TCF12
Molecular weight: 75,845 Da
Basal Isoelectric point: 6.4  Predict pI for various phosphorylation states
CST Pathways:  Adherens Junction Dynamics  |  Wnt/ß-Catenin Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

TCF12 iso3

Protein Structure Not Found.
Download PyMol Script
Download ChimeraX Script

cBioPortal  |  Wikipedia  |  Scansite  |  Pfam  |  RCSB PDB  |  Phospho3D  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene