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GSTP1 Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Regulates negatively CDK5 activity via p25/p35 translocation to prevent neurodegeneration. Homodimer. Interacts with CDK5. Belongs to the GST superfamily. Pi family. Note: This description may include information from UniProtKB.
Protein type: EC; Other Amino Acids Metabolism - glutathione; Transferase; Xenobiotic Metabolism - drug metabolism - cytochrome P450; Xenobiotic Metabolism - metabolism by cytochrome P450
Chromosomal Location of Human Ortholog: 11q13.2
Cellular Component: cytoplasm; cytosol; extracellular region; extracellular space; intracellular; mitochondrion; vesicle
Molecular Function: glutathione peroxidase activity; glutathione transferase activity; JUN kinase binding; kinase regulator activity; protein binding
Biological Process: central nervous system development; glutathione metabolic process; linoleic acid metabolic process; negative regulation of apoptosis; negative regulation of biosynthetic process; negative regulation of fibroblast proliferation; negative regulation of I-kappaB kinase/NF-kappaB cascade; negative regulation of interleukin-1 beta production; negative regulation of JNK activity; negative regulation of MAP kinase activity; negative regulation of nitric-oxide synthase biosynthetic process; negative regulation of protein kinase activity; negative regulation of stress-activated MAPK cascade; negative regulation of tumor necrosis factor production; neutrophil degranulation; positive regulation of superoxide release; regulation of stress-activated MAPK cascade; response to reactive oxygen species; xenobiotic metabolic process
Reference #:  P09211 (UniProtKB)
Alt. Names/Synonyms: deafness, X-linked 7; DFN7; FAEES3; fatty acid ethyl ester synthase III; Glutathione S-transferase P; glutathione S-transferase pi 1; GST class-pi; GST3; GSTP; GSTP1; GSTP1-1; PI
Gene Symbols: GSTP1
Molecular weight: 23,356 Da
Basal Isoelectric point: 5.43  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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