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Protein Page:

MEIS2 a homeobox protein belonging to the TALE ('three amino acid loop extension') family of homeodomain-containing proteins. TALE homeobox proteins are highly conserved transcription regulators, and several members have been shown to be essential contributors to developmental programs. Multiple transcript variants encoding distinct isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
Protein type: DNA-binding
Chromosomal Location of Human Ortholog: 15q14
Molecular Function: protein binding; transcription cofactor activity; transcription corepressor activity; transcription factor binding
Biological Process: negative regulation of myeloid cell differentiation; negative regulation of transcription from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase II promoter; transcription from RNA polymerase II promoter
Disease: Cleft Palate, Cardiac Defects, And Mental Retardation
Reference #:  O14770 (UniProtKB)
Alt. Names/Synonyms: Homeobox protein Meis2; HsT18361; Meis homeobox 2; Meis homolog 2; Meis1, myeloid ecotropic viral integration site 1 homolog 2; Meis1-related gene 1; Meis1-related protein 1; MEIS2; MGC2820; MRG1; TALE homeobox protein Meis2
Gene Symbols: MEIS2
Molecular weight: 51,790 Da
Basal Isoelectric point: 5.92  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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