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Cot an oncogenic Ser/Thr kinase of the STE group. Activates IkappaB kinases, thus inducing the nuclear translocation of NF-kappaB. Promotes the production of TNF-alpha and IL-2 during T lymphocyte activation. Interacts with NFkB-p105. Overexpressed and amplified in breast tumors. Viral insertions induce rat lymphomas and mouse mammary carcinomas. Isolated as a transforming factor in two cell lines. Mediates LPS activation of macrophages. 2 isoforms of the human protein are produced by alternative initiation. Note: This description may include information from UniProtKB.
Protein type: EC; Kinase, protein; Oncoprotein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor); STE group; STE-Unique family
Chromosomal Location of Human Ortholog: 10p11.23
Cellular Component: cytoplasm; cytosol
Molecular Function: MAP kinase kinase kinase activity; protein binding; protein serine/threonine kinase activity
Biological Process: activation of protein kinase activity; protein amino acid phosphorylation; regulation of apoptosis; regulation of mitotic cell cycle; stress-activated MAPK cascade; stress-activated protein kinase signaling pathway; T cell costimulation
Disease: Lung Cancer
Reference #:  P41279 (UniProtKB)
Alt. Names/Synonyms: c-COT; Cancer Osaka thyroid oncogene; COT; cot (cancer Osaka thyroid) oncogene; EST; ESTF; Ewing sarcoma transformant; FLJ10486; M3K8; MAP3K8; MEKK8; Mitogen-activated protein kinase kinase kinase 8; Proto-oncogene c-Cot; proto-oncogene serine/threoine protein kinase; Serine/threonine-protein kinase cot; TPL-2; TPL2; Tumor progression locus 2; tumor progression locus-2
Gene Symbols: MAP3K8
Molecular weight: 52,925 Da
Basal Isoelectric point: 5.54  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  B Cell Receptor Signaling  |  Growth And Differentiation Control by MAPKs  |  NF-kB Signaling  |  PI3K/Akt Signaling  |  SAPK/JNK Signaling Cascades
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