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Protein Page:
CXCR4

Overview
CXCR4 Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Involved in hematopoiesis and in cardiac ventricular septum formation. Also plays an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodeling processes in endothelial cells. Involved in cerebellar development. In the CNS, could mediate hippocampal-neuron survival. Acts as a coreceptor (CD4 being the primary receptor) for HIV-1 X4 isolates and as a primary receptor for some HIV-2 isolates. Promotes Env-mediated fusion of the virus. Monomer. Can form dimers. Interacts with CD164. Interacts with HIV-1 surface protein gp120 and Tat. Interacts with ARRB2; the interaction is dependent on the C-terminal phosphorylation of CXCR4 and allows activation of MAPK1 and MAPK3. Interacts with ARRC; the interaction is dependent on the C-terminal phosphorylation of CXCR4 and modulates calcium mobilization. Interacts (via the cytoplasmic C-terminal) with ITCH (via the WW domains I and II); the interaction, enhanced by CXCL12, ubiquitinates CXCR4 and leads to its degradation. Interacts with extracellular ubiquitin. Interacts with human cytomegalovirus/HHV- 5 protein UL78. Expressed in numerous tissues, such as peripheral blood leukocytes, spleen, thymus, spinal cord, heart, placenta, lung, liver, skeletal muscle, kidney, pancreas, cerebellum, cerebral cortex and medulla (in microglia as well as in astrocytes), brain microvascular, coronary artery and umbilical cord endothelial cells. Isoform 1 is predominant in all tissues tested. Belongs to the G-protein coupled receptor 1 family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR
Chromosomal Location of Human Ortholog: 2q22.1
Cellular Component: cell junction; cell leading edge; cell surface; cytoplasm; cytoplasmic vesicle; early endosome; integral component of membrane; late endosome; lysosome; plasma membrane; protein complex
Molecular Function: actin binding; C-C chemokine binding; C-X-C chemokine receptor activity; coreceptor activity; G-protein coupled receptor activity; myosin light chain binding; protein binding; ubiquitin binding; ubiquitin protein ligase binding; viral receptor activity
Biological Process: activation of MAPK activity; apoptosis; axon guidance; calcium-mediated signaling; dendritic cell chemotaxis; elevation of cytosolic calcium ion concentration; entry into host cell; fusion of virus membrane with host plasma membrane; G-protein coupled receptor signaling pathway; inflammatory response; myelin maintenance; positive regulation of oligodendrocyte differentiation; regulation of chemotaxis; response to hypoxia; response to virus
Disease: Whim Syndrome
Reference #:  P61073 (UniProtKB)
Alt. Names/Synonyms: C-X-C chemokine receptor type 4; CD184; CD184 antigen; chemokine (C-X-C motif) receptor 4; CXC-R4; CXCR-4; CXCR4; D2S201E; FB22; Fusin; HM89; HSY3RR; LAP3; LCR1; LESTR; Leukocyte-derived seven transmembrane domain receptor; leukocyte-derived seven-transmembrane-domain receptor; lipopolysaccharide-associated protein 3; neuropeptide Y receptor Y3; NPY3R; NPYR; NPYRL; NPYY3R; SDF-1 receptor; seven-transmembrane-segment receptor, spleen; Stromal cell-derived factor 1 receptor; WHIM
Gene Symbols: CXCR4
Molecular weight: 39,746 Da
Basal Isoelectric point: 8.46  Predict pI for various phosphorylation states
CST Pathways:  ErbB/HER Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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CXCR4

Protein Structure Not Found.
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