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AKAP1 Binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane. AKAP149 is highly expressed in prostate and small intestine whereas S-AKAP84 is expressed in kidney, pancreas, liver, lung and brain. AKAP149 is also expressed in colon carcinoma. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Membrane protein, integral; Mitochondrial; RNA-binding
Chromosomal Location of Human Ortholog: 11|11 C
Cellular Component: lipid particle; membrane; mitochondrial crista; mitochondrial inner membrane; mitochondrial matrix; mitochondrion; neuromuscular junction; postsynaptic membrane
Molecular Function: beta-tubulin binding; microtubule binding; protein binding; protein complex scaffold; protein domain specific binding; protein kinase binding; protein phosphatase 2B binding; protein phosphatase binding; RNA binding
Biological Process: negative regulation of NFAT protein import into nucleus; negative regulation of protein amino acid dephosphorylation
Reference #:  O08715 (UniProtKB)
Alt. Names/Synonyms: A kinase (PRKA) anchor protein 1; A kinase anchor protein 1, mitochondrial; Akap; Akap1; AKAP121; AKAP84; C76494; C81186; D-AKAP-1; DAKAP1; Dual specificity A-kinase-anchoring protein 1; OTTMUSP00000001248; OTTMUSP00000001249; PRKA1; Protein kinase A-anchoring protein 1; S-AKAP; S-AKAP84; Spermatid A-kinase anchor protein
Gene Symbols: Akap1
Molecular weight: 92,195 Da
Basal Isoelectric point: 4.91  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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