Binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane. AKAP149 is highly expressed in prostate and small intestine whereas S-AKAP84 is expressed in kidney, pancreas, liver, lung and brain. AKAP149 is also expressed in colon carcinoma. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Membrane protein, integral; Mitochondrial; RNA-binding
Molecular Function: beta-tubulin binding; microtubule binding; protein binding; protein complex scaffold; protein domain specific binding; protein kinase binding; protein phosphatase 2B binding; protein phosphatase binding; RNA binding
Biological Process: negative regulation of NFAT protein import into nucleus; negative regulation of protein amino acid dephosphorylation