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LATS2 an AGC kinase of the NDR family of kinases. A tumor suppressor of the LATS family. Plays a critical role in centrosome duplication, maintenance of mitotic fidelity and genomic stability. Inhibits cell growth at the G1/S transition by down-regulating cyclin E/CDK2 kinase activity. Negative regulator of the androgen receptor. Interacts with and is phosphorylated by STK6. Ectopic expression induces apoptosis in lung cancer cell lines. Negatively regulates androgen receptor, and is downregulated in prostate cancer Note: This description may include information from UniProtKB.
Protein type: AGC group; EC; Kinase, protein; NDR family; Nuclear receptor co-regulator; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor
Chromosomal Location of Human Ortholog: 13q12.11
Cellular Component: cytosol; microtubule organizing center; nucleus; spindle pole
Molecular Function: ATP binding; metal ion binding; protein binding; protein serine/threonine kinase activity
Biological Process: cell division; cellular protein localization; G1/S transition of mitotic cell cycle; hormone-mediated signaling pathway; inner cell mass cell fate commitment; inner cell mass cellular morphogenesis; keratinocyte differentiation; negative regulation of canonical Wnt signaling pathway; negative regulation of cyclin-dependent protein serine/threonine kinase activity; peptidyl-serine phosphorylation; positive regulation of apoptosis; protein amino acid phosphorylation; regulation of organ growth
Reference #:  Q9NRM7 (UniProtKB)
Alt. Names/Synonyms: FLJ13161; Kinase phosphorylated during mitosis protein; KPM; Large tumor suppressor homolog 2; LATS (large tumor suppressor, Drosophila) homolog 2; LATS, large tumor suppressor, homolog 2 (Drosophila); LATS2; serine/threonine kinase KPM; Serine/threonine-protein kinase kpm; Serine/threonine-protein kinase LATS2; Warts-like kinase
Gene Symbols: LATS2
Molecular weight: 120,136 Da
Basal Isoelectric point: 8.44  Predict pI for various phosphorylation states
CST Pathways:  Hippo Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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