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DRP1 Functions in mitochondrial and peroxisomal division. Mediates membrane fission through oligomerization into ring-like structures which wrap around the scission site to constict and sever the mitochondrial membrane through a GTP hydrolysis- dependent mechanism. Required for normal brain development. Facilitates developmentally-regulated apoptosis during neural tube development. Required for a normal rate of cytochrome c release and caspase activation during apoptosis. Also required for mitochondrial fission during mitosis. May be involved in vesicle transport. Homotetramer; dimerizes through the N-terminal GTP-middle region of one molecule binding to the GED domain of another DNM1L molecule. Can self-assemble in multimeric ring-like structures. Interacts with BCL2L1; the interaction stimulates the GTPase activity of DMN1L in synapses and increases the number of axonal mitochondria and the size and number of synaptic vesicle clusters. Interacts with FIS1. Interacts with GSK3B and MARCH5. Interacts (via the GTPase and B domains) with UBE2I; the interaction promotes sumoylation of DNM1L, mainly in ite B domain. Interacts with PPP3CA; the interaction dephosphorylates DNM1L and regulates its transition to mitochondria. Interacts witn MID49 and MID51. Ubiquitously expressed with highest levels found in skeletal muscles, heart, kidney and brain. Isoform 1 is brain-specific. Isoform 2 and isoform 3 are predominantly expressed in testis and skeletal muscles respectively. Isoform 4 is weakly expressed in brain, heart and kidney. Isoform 5 is dominantly expressed in liver, heart and kidney. Isoform 6 is expressed in neurons. Belongs to the dynamin family. 6 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Apoptosis; EC; Endoplasmic reticulum; Hydrolase; Microtubule-binding; Mitochondrial; Motor
Chromosomal Location of Human Ortholog: 12p11.21
Cellular Component: cytoplasm; cytosol; endoplasmic reticulum; endoplasmic reticulum membrane; Golgi apparatus; intracellular membrane-bound organelle; membrane; microtubule; mitochondrial outer membrane; mitochondrion; perinuclear region of cytoplasm; peroxisome; protein complex
Molecular Function: GTP-dependent protein binding; GTPase activator activity; GTPase activity; microtubule binding; protein binding; protein homodimerization activity; Rab GTPase binding; ubiquitin protein ligase binding
Biological Process: endoplasmic reticulum organization and biogenesis; intracellular distribution of mitochondria; mitochondrial fission; mitochondrial fragmentation during apoptosis; mitochondrion organization and biogenesis; peroxisome fission; positive regulation of apoptosis; positive regulation of protein secretion; protein homotetramerization; protein oligomerization; regulation of protein oligomerization; release of cytochrome c from mitochondria
Disease: Encephalopathy, Lethal, Due To Defective Mitochondrial And Peroxisomal Fission
Reference #:  O00429 (UniProtKB)
Alt. Names/Synonyms: DLP1; DNM1L; Dnm1p/Vps1p-like protein; DRP1; DVLP; Dymple; dynamin 1-like; Dynamin family member proline-rich carboxyl-terminal domain less; Dynamin-1-like protein; Dynamin-like protein; Dynamin-like protein 4; Dynamin-like protein IV; Dynamin-related protein 1; DYNIV-11; FLJ41912; HdynIV; VPS1
Gene Symbols: DNM1L
Molecular weight: 81,877 Da
Basal Isoelectric point: 6.37  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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