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SENP3 Protease that releases SUMO2 and SUMO3 monomers from sumoylated substrates, but has only weak activity against SUMO1 conjugates. Deconjugates SUMO2 from MEF2D, which increases its transcriptional activation capability. Deconjugates SUMO2 and SUMO3 from CDCA8. Redox sensor that, when redistributed into nucleoplasm, can act as an effector to enhance HIF1A transcriptional activity by desumoylating EP300. Required for rRNA processing through deconjugation of SUMO2 and SUMO3 from nucleophosmin, NPM1. Binds to SUMO1 and SUMO3. Component of some MLL1/MLL complex, at least composed of the core components MLL, ASH2L, HCFC1/HCF1, WDR5 and RBBP5, as well as the facultative components C17orf49, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, MYST1/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10. Interacts with EP300, NPM1 and CDCA8. On oxidative stress, SENP3 degradation is blocked by inhibition of its ubiquitination, which stabilizes it as it accumulates in the nucleoplasm. Belongs to the peptidase C48 family. Note: This description may include information from UniProtKB.
Protein type: EC; Nucleolus; Protease; Ubiquitin-specific protease
Chromosomal Location of Human Ortholog: 17p13.1
Cellular Component: nucleolus; nucleoplasm; nucleus
Molecular Function: endopeptidase activity; protein binding; SUMO-specific protease activity
Biological Process: protein desumoylation; rRNA processing
Reference #:  Q9H4L4 (UniProtKB)
Alt. Names/Synonyms: DKFZp586K0919; DKFZp762A152; SENP3; Sentrin-specific protease 3; sentrin/SUMO-specific protease 3; Sentrin/SUMO-specific protease SENP3; SMT3IP1; SSP3; SUMO-1-specific protease 3; SUMO1/sentrin/SMT3 specific peptidase 3; SUMO1/sentrin/SMT3 specific protease 3; SUSP3
Gene Symbols: SENP3
Molecular weight: 65,010 Da
Basal Isoelectric point: 8.82  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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