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PLK3 a kinase of the PLK family. Phosphorylated and activated following DNA damage or mitotic spindle disruption. Interacts with Chk2 and the interaction is enhanced upon DNA damage. Apparent substrates include Chk2 and p53. Plays an important role in regulating microtubule dynamics and centrosomal function. Deregulated expression of Plk3 results in cell cycle arrest and apoptosis. Note: This description may include information from UniProtKB.
Protein type: EC; Kinase, protein; Nucleolus; Other group; PLK family; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of Human Ortholog: 1p34.1
Cellular Component: centrosome; cytoplasm; Golgi stack; nucleolus; nucleoplasm; nucleus
Molecular Function: p53 binding; protein binding; protein serine/threonine kinase activity
Biological Process: apoptosis; cytoplasmic microtubule organization and biogenesis; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; endomitotic cell cycle; G1/S transition of mitotic cell cycle; G2/M transition of mitotic cell cycle; mitotic cell cycle checkpoint; negative regulation of apoptosis; negative regulation of transcription from RNA polymerase II promoter; protein kinase B signaling cascade; regulation of cell division; regulation of cytokinesis; response to DNA damage stimulus; response to osmotic stress; response to radiation; response to reactive oxygen species
Reference #:  Q9H4B4 (UniProtKB)
Alt. Names/Synonyms: CNK; cytokine-inducible kinase; Cytokine-inducible serine/threonine-protein kinase; FGF-inducible kinase; FNK; PLK-3; PLK3; Polo-like kinase 3; polo-like kinase 3 (Drosophila); PRK; Proliferation-related kinase; Serine/threonine-protein kinase PLK3
Gene Symbols: PLK3
Molecular weight: 71,629 Da
Basal Isoelectric point: 9.28  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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