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IkB-epsilon Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. Inhibits DNA-binding of NF-kappa-B p50-p65 and p50-c-Rel complexes. Interacts with RELA, REL, NFKB1 nuclear factor NF-kappa-B p50 subunit and NFKB2 nuclear factor NF-kappa-B p52 subunit. Highly expressed in spleen, testis and lung, followed by kidney, pancreas, heart, placenta and brain. Also expressed in granulocytes and macrophages. Belongs to the NF-kappa-B inhibitor family. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Inhibitor
Chromosomal Location of Human Ortholog: 6p21.1
Cellular Component: cytoplasm; cytosol; fibrillar center; nucleus
Molecular Function: protein binding
Biological Process: cytoplasmic sequestering of transcription factor
Reference #:  O00221 (UniProtKB)
Alt. Names/Synonyms: I-kappa-B-epsilon; IkappaBepsilon; IkB-E; IkB-epsilon; IKBE; NF-kappa-B inhibitor epsilon; NF-kappa-BIE; NFKBIE; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon
Gene Symbols: NFKBIE
Molecular weight: 52,864 Da
Basal Isoelectric point: 6.22  Predict pI for various phosphorylation states
CST Pathways:  B Cell Receptor Signaling  |  Death Receptor Signaling  |  Inhibition of Apoptosis  |  NF-kB Signaling  |  T Cell Receptor Signaling
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Protein Structure Not Found.

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