a dual-specificity protein kinase of the DYRK family. Localizes in the nucleus, where it enhances the transcriptional activity of TCF1/HNF1A. A co-activator of FKHR (FOXO1a)-dependent glucose-6-phosphatase gene expression. Induced by members of the Rho-family in myoblasts. Highest expression in skeletal muscle, testis, heart and brain with little expression in colon or lung. Expressed in a variety of tumor cell lines. Contains a bipartite nuclear targeting signal sequence. Three splice-variant isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: CMGC group; DYRK family; Dyrk1 subfamily; EC 126.96.36.199; Kinase, protein; Protein kinase, CMGC; Protein kinase, dual-specificity (non-receptor)