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Calreticulin Calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle. This lectin interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER. Interacts with the DNA-binding domain of NR3C1 and mediates its nuclear export. Involved in maternal gene expression regulation. May participate in oocyte maturation via the regulation of calcium homeostasis. Monomer. Component of an EIF2 complex at least composed of CELF1/CUGBP1, CALR, CALR3, EIF2S1, EIF2S2, HSP90B1 and HSPA5. Interacts with PDIA3/ERp57. Interacts with NR3C1 and TRIM21. Interacts with GABARAP. Belongs to the calreticulin family. Note: This description may include information from UniProtKB.
Protein type: Calcium-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 19p13.13
Cellular Component: cell surface; cytoplasm; cytosol; endoplasmic reticulum; endoplasmic reticulum lumen; ER-Golgi intermediate compartment membrane; extracellular region; extracellular space; focal adhesion; intracellular; membrane; nucleus; perinuclear region of cytoplasm; phagocytic vesicle membrane; polysome
Molecular Function: androgen receptor binding; calcium ion binding; carbohydrate binding; chaperone binding; complement component C1q binding; glycoprotein binding; integrin binding; mRNA binding; protein binding; RNA binding; ubiquitin protein ligase binding; unfolded protein binding; zinc ion binding
Biological Process: antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; antigen processing and presentation of peptide antigen via MHC class I; cellular calcium ion homeostasis; glucocorticoid receptor signaling pathway; negative regulation of neuron differentiation; negative regulation of retinoic acid receptor signaling pathway; negative regulation of steroid hormone receptor signaling pathway; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; negative regulation of translation; peptide antigen assembly with MHC class I protein complex; positive regulation of cell cycle; positive regulation of cell proliferation; positive regulation of DNA replication; positive regulation of phagocytosis; protein export from nucleus; protein folding; protein maturation via protein folding; protein stabilization; receptor-mediated endocytosis; regulation of apoptosis; regulation of transcription, DNA-dependent; sequestering of calcium ion
Disease: Myelofibrosis; Thrombocythemia 1
Reference #:  P27797 (UniProtKB)
Alt. Names/Synonyms: autoantigen Ro; CALR; Calregulin; Calreticulin; calreticulin); cC1qR; CRP55; CRT; CRTC; Endoplasmic reticulum resident protein 60; ERp60; FLJ26680; grp60; HACBP; RO; Sicca syndrome antigen A (autoantigen Ro; SSA
Gene Symbols: CALR
Molecular weight: 48,142 Da
Basal Isoelectric point: 4.29  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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