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CK1A an ubiquitous protein kinase of the CK1 family. Participates in Wnt signaling. Phosphorylates beta catenin, marking it for beta-TRCp-mediated ubiquitinylation and proteasomal degradation. Note: This description may include information from UniProtKB.
Protein type: CK1 group; CK1 family; EC; Kinase, protein; Protein kinase, CK1; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of Human Ortholog: 5q32
Cellular Component: beta-catenin destruction complex; centrosome; cilium; cytosol; keratin filament; membrane; mRNA cleavage and polyadenylation specificity factor complex; nuclear speck
Molecular Function: kinase activity; protein binding; protein kinase activity; protein serine/threonine kinase activity
Biological Process: cell surface receptor linked signal transduction; Golgi organization and biogenesis; intermediate filament cytoskeleton organization and biogenesis; peptidyl-serine phosphorylation; phagocytosis; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; proteasomal ubiquitin-dependent protein catabolic process; protein amino acid phosphorylation; regulation of cell shape; Wnt receptor signaling pathway
Reference #:  P48729 (UniProtKB)
Alt. Names/Synonyms: casein kinase 1, alpha 1; Casein kinase I isoform alpha; CK1; CKI-alpha; CSNK1A1; down-regulated in lung cancer; HLCDGP1; KC1A; PRO2975
Gene Symbols: CSNK1A1
Molecular weight: 38,915 Da
Basal Isoelectric point: 9.59  Predict pI for various phosphorylation states
CST Pathways:  Hedgehog Signaling  |  Wnt/ß-Catenin Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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