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CK1D an ubiquitous protein kinase of the CK1 family. Enriched at the centrosomes in interphase and at the spindle during mitosis. May play a role in cell cycle progression. Two splice variant isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: CK1 group; CK1 family; EC; EC; Kinase, protein; Protein kinase, CK1; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of Human Ortholog: 17q25.3
Cellular Component: centrosome; cytosol; ER-Golgi intermediate compartment membrane; Golgi apparatus; nucleoplasm; nucleus; perinuclear region of cytoplasm; plasma membrane; spindle; spindle microtubule
Molecular Function: cadherin binding; protein binding; protein kinase activity; protein serine/threonine kinase activity
Biological Process: circadian regulation of gene expression; COPII coating of Golgi vesicle; endocytosis; G2/M transition of mitotic cell cycle; Golgi organization and biogenesis; microtubule nucleation; peptidyl-serine phosphorylation; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of protein amino acid phosphorylation; protein amino acid phosphorylation; protein localization in Golgi apparatus; regulation of cell shape; regulation of circadian rhythm; rRNA processing; spindle assembly
Disease: Advanced Sleep Phase Syndrome, Familial, 2
Reference #:  P48730 (UniProtKB)
Alt. Names/Synonyms: casein kinase 1, delta; Casein kinase I isoform delta; CKI-delta; CKId; CSNK1D; HCKID; KC1D
Gene Symbols: CSNK1D
Molecular weight: 47,330 Da
Basal Isoelectric point: 9.77  Predict pI for various phosphorylation states
CST Pathways:  Hedgehog Signaling  |  Hippo Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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