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DCBLD2 a type-I transmembrane protein. May be involved in vascular remodeling and influence vascular smooth muscle cell proliferation. Contains a CUB domain and a coagulation factor V/VIII homology domain, similar to the structure of the neuropilins. Plays a role in cell motility. SEMA4B appears to be one of its ligands. Strongly expressed in nerve bundles. Highly expressed in testis, heart, skeletal muscle and also in cultured vascular smooth muscle cells. Increased in lung cancers during the process of tumor progression. A target of EGF signaling in the A431 cervical cancer cell-line. Two isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Cell adhesion; Membrane protein, integral
Chromosomal Location of Human Ortholog: 3q12.1|3
Cellular Component: cell surface; integral to plasma membrane
Molecular Function: protein binding
Biological Process: negative regulation of cell growth; wound healing
Reference #:  Q96PD2 (UniProtKB)
Alt. Names/Synonyms: 1700055P21Rik; CLCP1; coagulation factor V/VIII-homology domains protein 1; CUB, LCCL and coagulation factor V/VIII-homology domains protein 1; DCBD2; DCBLD2; discoidin, CUB and LCCL domain containing 2; Discoidin, CUB and LCCL domain-containing protein 2; Endothelial and smooth muscle cell-derived neuropilin-like protein; ESDN
Gene Symbols: DCBLD2
Molecular weight: 85,035 Da
Basal Isoelectric point: 6.77  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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