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Alix an adaptor protein that may regulate the function of receptor and cytoskeleton-associated tyrosine kinases. A class E vacuolar protein sorting (VPS) factor involved in concentration and sorting of cargo proteins of the multivesicular body (MVB) for incorporation into intralumenal vesicles. Fusion between endosomes and the vacuole will then target the cargo proteins to the vacuolar lumen. In case of infection, the HIV-1 virus directly takes advantage of its function for viral exocytosis and budding, via its interaction with HIV-1 p6 protein. May play a role in the regulation of both apoptosis and cell proliferation. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Apoptosis
Chromosomal Location of Human Ortholog: 3p22.3
Cellular Component: actomyosin; cytosol; focal adhesion; immunological synapse; membrane
Molecular Function: calcium-dependent protein binding; protein binding; protein homodimerization activity; proteinase activated receptor binding
Biological Process: cell separation during cytokinesis; cytokinesis after mitosis; cytokinesis, contractile ring formation; maintenance of epithelial cell polarity; mitotic metaphase plate congression; non-lytic virus budding; nuclear organization and biogenesis; protein homooligomerization; viral infectious cycle
Reference #:  Q8WUM4 (UniProtKB)
Alt. Names/Synonyms: AIP1; ALG-2 interacting protein 1; ALG-2 interacting protein X; ALG-2-interacting protein 1; ALIX; apoptosis-linked gene 2-interacting protein X; dopamine receptor interacting protein 4; DRIP4; Hp95; KIAA1375; MGC17003; PDC6I; PDCD6-interacting protein; PDCD6IP; programmed cell death 6 interacting protein; Programmed cell death 6-interacting protein
Gene Symbols: PDCD6IP
Molecular weight: 96,023 Da
Basal Isoelectric point: 6.13  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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