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SPRY1 May function as an antagonist of fibroblast growth factor (FGF) pathways and may negatively modulate respiratory organogenesis. Belongs to the sprouty family. Induced by FGF signaling. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Inhibitor; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 4q28.1
Cellular Component: cytosol; Golgi apparatus; nucleoplasm; plasma membrane
Molecular Function: protein binding
Biological Process: negative regulation of epidermal growth factor receptor signaling pathway
Reference #:  O43609 (UniProtKB)
Alt. Names/Synonyms: hSPRY1; Protein sprouty homolog 1; sprouty homolog 1, antagonist of FGF signaling (Drosophila); sprouty, Drosophila, homolog of, 1 (antagonist of FGF signaling); Spry-1; SPRY1; SPY1
Gene Symbols: SPRY1
Molecular weight: 35,122 Da
Basal Isoelectric point: 8.65  Predict pI for various phosphorylation states
CST Pathways:  ErbB/HER Signaling  |  Growth And Differentiation Control by MAPKs
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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