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CAMK2B a widely expressed protein kinase of the calcium/calmodulin-dependent protein kinase (CAMK) group. Functions autonomously after Ca2+/calmodulin-binding and autophosphorylation. Involved in dendritic spine and synapse formation, neuronal plasticity and regulation of sarcoplasmic reticulum Ca2+ transport in skeletal muscle. In neurons, plays an essential structural role in the reorganization of the actin cytoskeleton during plasticity by binding and bundling actin filaments in a kinase-independent manner. This structural function is required for correct targeting of CaMK2A, which acts downstream of NMDAR to promote dendritic spine and synapse formation and maintain synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning. In developing hippocampal neurons, promotes arborization of the dendritic tree and in mature neurons, promotes dendritic remodeling. Participates in the modulation of skeletal muscle function in response to exercise. In slow-twitch muscles, is involved in regulation of sarcoplasmic reticulum (SR) Ca2+ transport and in fast-twitch muscle participates in the control of Ca2+ release from the SR through phosphorylation of triadin, a ryanodine receptor-coupling factor, and phospholamban, an endogenous inhibitor of SERCA2. The holoenzyme is composed of 4 different chains: alpha (CAMK2A), beta (CAMK2B), gamma (CAMK2G), and delta (CAMK2D). The different isoforms assemble into homo- or heteromultimeric holoenzymes composed of 12 subunits with two hexameric rings stacked one on top of the other. Interacts with SYNGAP1 and CAMK2N2. Interacts with MPDZ. Expressed in adult and fetal brain. Expression is slightly lower in fetal brain. Expressed in skeletal muscle and induced during exercise. Eight isoforms of the human protein are produced by alternative splicing.
Protein type: CAMK group; CAMK2 family; EC; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of Human Ortholog: 7p13
Cellular Component: cytoplasm; cytosol; microtubule organizing center; neuron projection; nucleoplasm; plasma membrane; sarcoplasmic reticulum membrane
Molecular Function: actin binding; ATP binding; calmodulin binding; calmodulin-dependent protein kinase activity; identical protein binding; protein binding; protein homodimerization activity; protein serine/threonine kinase activity; Ras guanyl-nucleotide exchange factor activity
Biological Process: MAPK cascade; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; positive regulation of neuron projection development; positive regulation of synapse maturation; protein amino acid phosphorylation; protein autophosphorylation; regulation of calcium ion transport; regulation of cellular response to heat; regulation of long-term neuronal synaptic plasticity; regulation of molecular function; regulation of skeletal muscle adaptation; regulation of synapse structural plasticity; signal transduction
Disease: Mental Retardation, Autosomal Dominant 54
Reference #:  Q13554 (UniProtKB)
Alt. Names/Synonyms: calcium/calmodulin-dependent protein kinase II beta; calcium/calmodulin-dependent protein kinase type II beta chain; Calcium/calmodulin-dependent protein kinase type II subunit beta; CaM kinase II beta subunit; CaM kinase II subunit beta; CaM-kinase II beta chain; CAM2; CaMK-II subunit beta; CAMK2; CaMK2-beta; CAMK2B; CAMKB; CaMKII; KCC2B; MGC29528; proline rich calmodulin-dependent protein kinase
Gene Symbols: CAMK2B
Molecular weight: 72,678 Da
Basal Isoelectric point: 6.87  Predict pI for various phosphorylation states
CST Pathways:  B Cell Receptor Signaling  |  ErbB/HER Signaling  |  GPCR Signaling to MAPKs  |  Microtubule Dynamics  |  Mitochondrial Control of Apoptosis  |  Phospholipase Signaling
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