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SOX2 Transcription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. Critical for early embryogenesis and for embryonic stem cell pluripotency. May function as a switch in neuronal development. Downstream SRRT target that mediates the promotion of neural stem cell self-renewal. Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation. Interacts with ZSCAN10. Interacts with SOX3 and FGFR1. Note: This description may include information from UniProtKB.
Protein type: Cell development/differentiation; DNA-binding; Transcription factor
Chromosomal Location of Human Ortholog: 3q26.33
Cellular Component: cytoplasm; cytosol; nucleoplasm; nucleus; transcription factor complex
Molecular Function: DNA binding; miRNA binding; protein binding; sequence-specific DNA binding; transcription factor activity
Biological Process: cell cycle arrest; endodermal cell fate specification; eye development; forebrain development; inner ear development; negative regulation of epithelial cell proliferation; negative regulation of neuron differentiation; negative regulation of transcription from RNA polymerase II promoter; osteoblast differentiation; pituitary gland development; positive regulation of MAPKKK cascade; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; regulation of caspase activity; regulation of gene expression; regulation of transcription, DNA-dependent; response to wounding; somatic stem cell maintenance
Disease: Microphthalmia, Syndromic 3; Tracheoesophageal Fistula With Or Without Esophageal Atresia
Reference #:  P48431 (UniProtKB)
Alt. Names/Synonyms: ANOP3; MCOPS3; MGC2413; SOX2; SRY (sex determining region Y)-box 2; SRY-related HMG-box gene 2; Transcription factor SOX-2; transcription factor SOX2
Gene Symbols: SOX2
Molecular weight: 34,310 Da
Basal Isoelectric point: 9.74  Predict pI for various phosphorylation states
CST Pathways:  ESC Pluripotency and Differentiation
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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