an AGC kinase. Plays critical roles in glucose metabolism and the development or maintenance of proper adipose tissue and islet mass for which other Akt/PKB isoforms are unable to fully compensate. Amplified and overexpressed in human ovarian carcinoma cell lines and amplified in some primary ovarian and pancreatic tumors. Antisense blocks invasiveness in xenografts. Expressed in several insulin-responsive tissues, and one case of Type II diabetes has been associated with a likely LOF point mutation. Mouse mutants have defects in insulin response. Note: This description may include information from UniProtKB.
Protein type: AGC group; AKT family; EC 220.127.116.11; Kinase, protein; Oncoprotein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)
Cellular Component: cell cortex; cytosol; early endosome; intracellular membrane-bound organelle; nucleoplasm; nucleus; plasma membrane; protein complex
Molecular Function: ATP binding; metal ion binding; protein binding; protein serine/threonine kinase activity
Biological Process: carbohydrate transport; cellular protein modification process; cellular response to high light intensity; cellular response to insulin stimulus; fat cell differentiation; glucose metabolic process; glycogen biosynthetic process; insulin receptor signaling pathway; intracellular protein transmembrane transport; negative regulation of apoptosis; negative regulation of plasma membrane long-chain fatty acid transport; peptidyl-serine phosphorylation; peripheral nervous system myelin maintenance; positive regulation of cell migration; positive regulation of cell motility; positive regulation of cell proliferation; positive regulation of fatty acid beta-oxidation; positive regulation of glucose import; positive regulation of glucose import in response to insulin stimulus; positive regulation of glucose metabolic process; positive regulation of glycogen biosynthetic process; positive regulation of mitochondrial membrane potential; positive regulation of protein phosphorylation; positive regulation of protein targeting to membrane; positive regulation of vesicle fusion; protein localization to plasma membrane; regulation of cell cycle arrest; regulation of cell migration; regulation of translation; signal transduction