Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
Home | Login
About PhosphoSiteUsing PhosphoSiteprivacy & cookiesCuration ProcessContact
logos LINCs Logo Mt Sinai Logo NIH Logo NCI Logo
Search / Browse Functions
Protein Page:

NGFR Low affinity receptor which can bind to NGF, BDNF, NT-3, and NT-4. Can mediate cell survival as well as cell death of neural cells. Homodimer; disulfide-linked. Interacts with p75NTR- associated cell death executor. Interacts with TRAF2, TRAF4, TRAF6, PTPN13 and RANBP9. Interacts through TRAF6 with SQSTM1 which bridges NGFR to NTRK1. Interacts with BEX1 and NGFRAP1/BEX3. Interacts with KIDINS220 and NTRK1. Can form a ternary complex with NTRK1 and KIDINS220 and this complex is affected by the expression levels of KIDINS220. An increase in KIDINS220 expression leads to a decreased association of NGFR and NTRK1. Interacts with NTRK2; may regulate the ligand specificity of the NTRK2 receptor. Interacts with LINGO1. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Receptor, misc.
Chromosomal Location of Human Ortholog: 17q21.33
Cellular Component: cell surface; cytosol; endosome; extracellular region; integral component of membrane; integral component of plasma membrane; neuron projection; nucleoplasm; nucleus; plasma membrane
Molecular Function: calmodulin binding; coreceptor activity; death receptor activity; nerve growth factor binding; neurotrophin binding; protein binding; Rab GTPase binding; receptor activity; signal transducer activity; transmembrane receptor activity; tumor necrosis factor-activated receptor activity; ubiquitin protein ligase binding
Biological Process: activation of cysteine-type endopeptidase activity involved in apoptotic process; axon guidance; circadian regulation of gene expression; glucose homeostasis; immune response; inflammatory response; intracellular protein transport; membrane protein intracellular domain proteolysis; negative regulation of apoptosis; negative regulation of axonogenesis; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; nerve growth factor receptor signaling pathway; neuron apoptosis; positive regulation of apoptosis; positive regulation of axonogenesis; regulation of caspase activity; response to lipopolysaccharide; Rho protein signal transduction; tumor necrosis factor-mediated signaling pathway
Reference #:  P08138 (UniProtKB)
Alt. Names/Synonyms: CD271; Gp80-LNGFR; low affinity nerve growth factor receptor; Low affinity neurotrophin receptor p75NTR; Low-affinity nerve growth factor receptor; nerve growth factor receptor (TNFR superfamily, member 16); NGF receptor; NGFR; p75 ICD; p75(NTR); p75NTR; TNFRSF16; TNR16; Tumor necrosis factor receptor superfamily member 16
Gene Symbols: NGFR
Molecular weight: 45,183 Da
Basal Isoelectric point: 4.59  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below


Protein Structure Not Found.
Download PyMol Script
Download ChimeraX Script

STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Scansite  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene