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TGFBR1 a TKL kinase of the serine/threonine-protein kinase receptor (STKR) family. R1 and R2 TGF-beta receptors dimerize after binding TGF-beta at the cell surface. Found in all tissues; most abundant in placenta and least abundant in brain and heart. Note: This description may include information from UniProtKB.
Protein type: EC; Kinase, protein; Membrane protein, integral; Protein kinase, Ser/Thr (receptor); Protein kinase, TKL; Receptor, misc.; STKR family; TKL group; Type1 subfamily
Chromosomal Location of Human Ortholog: 9q22.33
Cellular Component: cell surface; intracellular membrane-bound organelle; lipid raft; plasma membrane; receptor complex; tight junction
Molecular Function: ATP binding; growth factor binding; protein binding; protein kinase activity; protein serine/threonine kinase activity; punt binding; receptor signaling protein activity; SMAD binding; transforming growth factor beta binding; transforming growth factor beta receptor activity; transforming growth factor beta receptor activity, type I
Biological Process: activation of MAPKK activity; activin receptor signaling pathway; anterior/posterior pattern formation; artery morphogenesis; cell cycle arrest; cell motility involved in cell locomotion; collagen fibril organization; embryonic cranial skeleton morphogenesis; endothelial cell activation; epithelial to mesenchymal transition; extracellular structure organization and biogenesis; germ cell migration; heart development; in utero embryonic development; kidney development; mesenchymal cell differentiation; negative regulation of chondrocyte differentiation; negative regulation of transforming growth factor beta receptor signaling pathway; neuron fate commitment; palate development; parathyroid gland development; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; pharyngeal system development; positive regulation of cell growth; positive regulation of cell migration; positive regulation of cell motility; positive regulation of cell proliferation; positive regulation of endothelial cell proliferation; positive regulation of protein kinase B signaling cascade; positive regulation of stress fiber formation; positive regulation of transcription, DNA-dependent; protein amino acid phosphorylation; protein deubiquitination; regulation of cardiac muscle cell proliferation; regulation of protein ubiquitination; regulation of transcription, DNA-dependent; signal transduction; skeletal development; skeletal morphogenesis; thymus development; transforming growth factor beta receptor signaling pathway; wound healing
Disease: Multiple Self-healing Squamous Epithelioma, Susceptibility To
Reference #:  P36897 (UniProtKB)
Alt. Names/Synonyms: AAT5; activin A receptor type II-like kinase, 53kD; activin A receptor type II-like kinase, 53kDa; Activin receptor-like kinase 5; ACVRLK4; ALK-5; ALK5; LDS1A; LDS2A; Serine/threonine-protein kinase receptor R4; SKR4; TbetaR-I; TGF-beta receptor type I; TGF-beta receptor type-1; TGF-beta type I receptor; TGFBR1; TGFR-1; TGFR1; transforming growth factor beta receptor I; transforming growth factor, beta receptor 1; transforming growth factor, beta receptor I (activin A receptor type II-like kinase, 53kD); Transforming growth factor-beta receptor type I
Gene Symbols: TGFBR1
Molecular weight: 55,960 Da
Basal Isoelectric point: 7.51  Predict pI for various phosphorylation states
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