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Syk a cytoplasmic tyrosine kinase of the SYK family containing two SH2 domains. Plays a central role in the B cell receptor (BCR) response. An upstream activator of the PI3K, PLCgamma2, and Rac/cdc42 pathways in the BCR response. Required for the sequential events of Fc gamma IIa receptor-mediated phagocytosis. Expression highest in murine spleen, heart, mammary gland and thymus. Two splice variant isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: EC; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor); Syk family; TK group
Chromosomal Location of Human Ortholog: 9q22.2
Cellular Component: cytoplasm; cytosol; extrinsic to internal side of plasma membrane; nucleus; plasma membrane; protein complex; T cell receptor complex
Molecular Function: integrin binding; non-membrane spanning protein tyrosine kinase activity; phosphotyrosine binding; protein binding; protein kinase activity; protein serine/threonine kinase activity; protein-tyrosine kinase activity
Biological Process: adaptive immune response; B cell receptor signaling pathway; blood vessel morphogenesis; cell proliferation; defense response to bacterium; inflammatory response; innate immune response; integrin-mediated signaling pathway; leukocyte activation during immune response; leukocyte adhesion; lymph vessel development; macrophage activation during immune response; neutrophil activation during immune response; neutrophil chemotaxis; organ morphogenesis; platelet activation; positive regulation of alpha-beta T cell proliferation; positive regulation of B cell differentiation; positive regulation of bone resorption; positive regulation of cell adhesion mediated by integrin; positive regulation of mast cell degranulation; protein amino acid phosphorylation; receptor internalization; regulation of neutrophil degranulation; regulation of phagocytosis; regulation of superoxide release; regulation of transcription factor activity; serotonin secretion by platelet; stimulatory C-type lectin receptor signaling pathway; transcription factor import into nucleus; transmembrane receptor protein tyrosine kinase signaling pathway
Reference #:  P43405 (UniProtKB)
Alt. Names/Synonyms: DKFZp313N1010; FLJ25043; FLJ37489; KSYK; Spleen tyrosine kinase; SYK; Tyrosine-protein kinase SYK
Gene Symbols: SYK
Molecular weight: 72,066 Da
Basal Isoelectric point: 8.43  Predict pI for various phosphorylation states
CST Pathways:  B Cell Receptor Signaling  |  ErbB/HER Signaling  |  PI3K/Akt Signaling  |  Tyrosine Kinases & Substrates
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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