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SGK1 serum and glucocorticoid-inducible kinase is an AGC protein kinase of the SGK family. Rapidly induced in response to a variety of stimuli including serum, glucocorticoids, follicle stimulating hormone, osmotic shock and mineralocorticoids. Can be activated via PI3K-dependent and -independent pathways. Plays a role in activating certain potassium, sodium and chloride channels, suggesting an involvement in the regulation of processes such as cell survival, neuronal excitability and renal sodium excretion. SGK is negatively regulated by ubiquitin modification and proteasome degradation. Note: This description may include information from UniProtKB.
Protein type: AGC group; EC; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); SGK family
Chromosomal Location of Human Ortholog: 6q23.2
Cellular Component: cytoplasm; cytosol; nuclear speck; nucleus
Molecular Function: calcium channel regulator activity; chloride channel regulator activity; potassium channel regulator activity; protein binding; protein serine/threonine kinase activity; protein serine/threonine/tyrosine kinase activity; sodium channel regulator activity
Biological Process: long-term memory; neurite morphogenesis; peptidyl-serine phosphorylation; positive regulation of transporter activity; protein amino acid phosphorylation; regulation of apoptosis; regulation of blood pressure; regulation of catalytic activity; regulation of cell growth; regulation of cell migration; regulation of cell proliferation; regulation of transcription factor activity; response to stress; sodium ion transport
Reference #:  O00141 (UniProtKB)
Alt. Names/Synonyms: serine/threonine protein kinase SGK; Serine/threonine-protein kinase Sgk1; serum/glucocorticoid regulated kinase 1; Serum/glucocorticoid-regulated kinase 1; SGK; SGK1
Gene Symbols: SGK1
Molecular weight: 48,942 Da
Basal Isoelectric point: 8.7  Predict pI for various phosphorylation states
CST Pathways:  Insulin Receptor Signaling  |  mTOR Signaling
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