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DOCK1 Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Functions as a guanine nucleotide exchange factor (GEF), which activates Rac Rho small GTPases by exchanging bound GDP for free GTP. Its GEF activity may be enhanced by ELMO1. Interacts with the SH3 domains of CRK and NCK2 via multiple sites. Interacts with nucleotide-free RAC1 via its DHR-2 domain. Interacts with ELMO1, ELMO2 and probably ELMO3 via its SH3 domain. Interacts with RAC1 and BAI1. Highly expressed in placenta, lung, kidney, pancreas and ovary. Expressed at intermediate level in thymus, testes and colon. Belongs to the DOCK family. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Cytoskeletal; GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 10q26.2
Cellular Component: cytoplasm; cytosol
Molecular Function: guanyl-nucleotide exchange factor activity; protein binding; Rho guanyl-nucleotide exchange factor activity
Biological Process: blood coagulation; integrin-mediated signaling pathway; phagocytosis, engulfment; signal transduction; vascular endothelial growth factor receptor signaling pathway
Reference #:  Q14185 (UniProtKB)
Alt. Names/Synonyms: 180 kDa protein downstream of CRK; ced5; dedicator of cyto-kinesis 1; dedicator of cytokinesis 1; Dedicator of cytokinesis protein 1; DOCK1; DOCK180; DOwnstream of CrK
Gene Symbols: DOCK1
Molecular weight: 215,346 Da
Basal Isoelectric point: 7.29  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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