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PLK1 a kinase of the PLK family. Contains a polo-box domain (PBD), a specific phosphoserine or phosphothreonine binding domain. Substrates include BRCA2, Myt1, NudC, Cdc25C, cyclin B1, Nlp and other mitotic proteins. Inhibited by ATR. Plays a role in regulation of cytokinesis and coordinating M-phase events. Note: This description may include information from UniProtKB.
Protein type: EC; Kinase, protein; Other group; PLK family; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of Human Ortholog: 16p12.2
Cellular Component: centrosome; chromatin; condensed nuclear chromosome outer kinetochore; cytosol; kinetochore; microtubule cytoskeleton; midbody; nucleoplasm; nucleus; spindle; spindle microtubule; spindle midzone; spindle pole; synaptonemal complex
Molecular Function: anaphase-promoting complex binding; ATP binding; identical protein binding; kinase activity; magnesium ion binding; microtubule binding; protein binding; protein kinase activity; protein kinase binding; protein serine/threonine kinase activity
Biological Process: anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; cell proliferation; centrosome cycle; establishment of protein localization; female meiosis chromosome segregation; G2/M transition of mitotic cell cycle; homologous chromosome segregation; microtubule bundle formation; mitotic cell cycle; mitotic cell cycle spindle assembly checkpoint; mitotic cytokinesis; mitotic nuclear envelope disassembly; mitotic sister chromatid segregation; negative regulation of apoptosis; negative regulation of cyclin-dependent protein serine/threonine kinase activity; negative regulation of transcription from RNA polymerase II promoter; nuclear envelope disassembly; peptidyl-serine phosphorylation; positive regulation of peptidyl-threonine phosphorylation; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of protein localization to nucleus; positive regulation of proteolysis; positive regulation of ubiquitin protein ligase activity; positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle; positive regulation of ubiquitin-protein transferase activity; protein amino acid phosphorylation; protein destabilization; protein localization to chromatin; protein localization to nuclear envelope; protein ubiquitination; protein ubiquitination involved in ubiquitin-dependent protein catabolic process; regulation of cell cycle; regulation of cell cycle G2/M phase transition; regulation of cytokinesis; regulation of G2/M transition of mitotic cell cycle; regulation of mitotic cell cycle; regulation of mitotic metaphase/anaphase transition; regulation of mitotic spindle assembly; regulation of protein binding; regulation of ubiquitin-protein ligase activity during mitotic cell cycle; signal transduction involved in G2 DNA damage checkpoint; sister chromatid cohesion
Reference #:  P53350 (UniProtKB)
Alt. Names/Synonyms: cell cycle regulated protein kinase; PLK; PLK-1; PLK1; polo (Drosophia)-like kinase; polo like kinase; Polo-like kinase 1; polo-like kinase 1 (Drosophila); Serine/threonine-protein kinase 13; Serine/threonine-protein kinase PLK1; STPK13
Gene Symbols: PLK1
Molecular weight: 68,255 Da
Basal Isoelectric point: 9.09  Predict pI for various phosphorylation states
CST Pathways:  G2/M DNA Damage Checkpoint
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