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SH2D1A Inhibitor of the SLAM self-association. Acts by blocking recruitment of the SH2-domain-containing signal-transduction molecule SHP-2 to a docking site in the SLAM cytoplasmic region. Mediates interaction between FYN and SLAMF1. May also regulate the activity of the neurotrophin receptors NTRK1, NTRK2 and NTRK3. Interacts with NTRK1, NTRK2 and NTRK3. Interacts with CD84, CD244, LY9, SLAMF1 and FYN. Expressed at a high level in thymus and lung, with a lower level of expression in spleen and liver. Expressed in peripheral blood leukocytes, including T lymphocytes. Tends to be expressed at lower levels in peripheral blood leukocytes in patients with rheumatoid arthritis. 6 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Apoptosis
Chromosomal Location of Human Ortholog: Xq25
Cellular Component: cytoplasm; cytosol
Molecular Function: protein binding
Biological Process: cell-cell signaling; regulation of immune response
Disease: Lymphoproliferative Syndrome, X-linked, 1
Reference #:  O60880 (UniProtKB)
Alt. Names/Synonyms: DSHP; Duncan disease SH2-protein; Duncan's disease; EBVS; FLJ18687; FLJ92177; IMD5; LYP; MTCP1; SAP; SH2 domain containing 1A; SH2 domain protein 1A; SH2 domain-containing protein 1A; SH21A; SH2D1A; signaling lymphocyte activation molecule-associated protein; Signaling lymphocytic activation molecule-associated protein; SLAM-associated protein; T cell signal transduction molecule SAP; T-cell signal transduction molecule SAP; XLP; XLPD
Gene Symbols: SH2D1A
Molecular weight: 14,187 Da
Basal Isoelectric point: 8.74  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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