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SKAR Is involved in regulation of translation. Is preferentially associated with CBC-bound spliced mRNA-protein complexes during the pioneer round of mRNA translation. Contributes to enhanced translational efficiency of spliced over nonspliced mRNAs. Recruits activated ribosomal protein S6 kinase beta-1 I/RPS6KB1 to newly synthesized mRNA. Interacts with POLD2. Interacts with NCBP1 and EIF4A3. Associates with the multiprotein exon junction complex (EJC). Interacts with RPS6KB1 (activated). Interacts with ERH. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: RNA-binding
Chromosomal Location of Human Ortholog: 22q13.2
Cellular Component: cytoplasm; cytosol; nuclear speck; nucleoplasm
Molecular Function: protein binding; RNA binding
Biological Process: mRNA 3'-end processing; mRNA export from nucleus; poly(A)+ mRNA export from nucleus; positive regulation of translation; RNA export from nucleus; termination of RNA polymerase II transcription
Reference #:  Q9BY77 (UniProtKB)
Alt. Names/Synonyms: 46 kDa DNA polymerase delta interaction protein; KIAA1649; p46; PDIP3; PDIP46; POLDIP3; polymerase (DNA-directed), delta interacting protein 3; polymerase delta interacting protein 46; Polymerase delta-interacting protein 3; RNA-binding protein P46; S6K1 Aly/REF-like target; SKAR
Gene Symbols: POLDIP3
Molecular weight: 46,089 Da
Basal Isoelectric point: 10  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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