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PKR a protein kinase of the PEK family. Upon binding double-stranded RNA, it becomes autophosphorylated and activated. Phosphorylates and inhibits the alpha subunit of eIF2 alpha, which leads to an inhibition of the initiation of protein synthesis. Controls the activation of several transcription factors such as NF-kappaB, p53 and Stats. Mediates apoptosis induced by many different stimuli, such as LPS, TNF-alpha, viral infection and serum starvation. Note: This description may include information from UniProtKB.
Protein type: EC; EC; Kinase, protein; Other group; PEK family; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Translation
Chromosomal Location of Human Ortholog: 2p22.2
Cellular Component: cytoplasm; cytosol; membrane; perinuclear region of cytoplasm; ribosome
Molecular Function: double-stranded RNA binding; eukaryotic translation initiation factor 2alpha kinase activity; protein binding; protein kinase activity; protein phosphatase regulator activity; protein serine/threonine kinase activity; RNA binding
Biological Process: activation of MAPKK activity; activation of NF-kappaB transcription factor; cellular response to amino acid starvation; evasion by virus of host immune response; negative regulation of cell proliferation; negative regulation of osteoblast proliferation; negative regulation of translation; negative regulation of viral genome replication; positive regulation of chemokine production; positive regulation of cytokine production; positive regulation of stress-activated MAPK cascade; protein amino acid autophosphorylation; protein amino acid phosphorylation; response to virus
Reference #:  P19525 (UniProtKB)
Alt. Names/Synonyms: double stranded RNA activated protein kinase; E2AK2; eIF-2A protein kinase 2; EIF2AK1; EIF2AK2; Eukaryotic translation initiation factor 2-alpha kinase 2; Interferon-induced, double-stranded RNA-activated protein kinase; interferon-inducible elF2alpha kinase; Interferon-inducible RNA-dependent protein kinase; MGC126524; P1/eIF-2A protein kinase; p68 kinase; PKR; PRKR; Protein kinase RNA-activated; protein kinase, interferon-inducible double stranded RNA dependent
Gene Symbols: EIF2AK2
Molecular weight: 62,094 Da
Basal Isoelectric point: 8.58  Predict pI for various phosphorylation states
CST Pathways:  Translation: eIF2
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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