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PKCI an AGC protein kinase of the PKC family. A calcium-independent, phospholipid-dependent atypical protein kinase C. Is not activated by phorbolesters or diaglycerol. May play role in the secretory response to nutrients. Involved in cell polarization processes and the formation of epithelial tight junctions. Predominantly expressed in lung and brain, but also expressed at lower levels in many tissues including pancreatic islets. Note: This description may include information from UniProtKB.
Protein type: AGC group; Cell adhesion; Cell development/differentiation; EC; Iota subfamily; Kinase, protein; Motility/polarity/chemotaxis; Oncoprotein; PKC family; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor
Chromosomal Location of Human Ortholog: 3q26.2
Cellular Component: cytosol; intercellular bridge; microtubule cytoskeleton; nucleus; plasma membrane
Molecular Function: ATP binding; phospholipid binding; protein binding; protein kinase activity; protein kinase C activity; protein serine/threonine kinase activity
Biological Process: activation of NF-kappaB transcription factor; cellular response to insulin stimulus; establishment and/or maintenance of epithelial cell polarity; intercellular junction assembly and maintenance; negative regulation of apoptosis; negative regulation of neuron apoptosis; peptidyl-serine phosphorylation; positive regulation of glucose import; protein amino acid phosphorylation; vesicle-mediated transport
Reference #:  P41743 (UniProtKB)
Alt. Names/Synonyms: aPKC-lambda/iota; Atypical protein kinase C-lambda/iota; DXS1179E; KPCI; MGC26534; nPKC-iota; PKCI; PRKC-lambda/iota; PRKCI; Protein kinase C iota type; protein kinase C, iota
Gene Symbols: PRKCI
Molecular weight: 68,262 Da
Basal Isoelectric point: 5.54  Predict pI for various phosphorylation states
CST Pathways:  Apoptosis Regulation  |  B Cell Receptor Signaling  |  ErbB/HER Signaling  |  GPCR Signaling to MAPKs  |  Growth And Differentiation Control by MAPKs  |  Inhibition of Apoptosis  |  Insulin Receptor Signaling  |  Mitochondrial Control of Apoptosis  |  Phospholipase Signaling  |  Protein Kinase C Signaling  |  TGF-ß Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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