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TD-60 Required for completion of mitosis and cytokinesis. May function as a guanine nucleotide exchange factor for the small GTPase RAC1. Binds preferentially to the nucleotide-free form of RAC1. Interacts with microtubules. Note: This description may include information from UniProtKB.
Protein type: GEF; GEF, misc.; Nucleolus
Chromosomal Location of Human Ortholog: 1p36.13
Cellular Component: cytosol; membrane; midbody
Molecular Function: microtubule binding; protein binding; protein domain specific binding; protein kinase binding; Rac GTPase binding; RNA binding; small GTPase binding
Biological Process: focal adhesion formation; integrin-mediated signaling pathway; negative regulation of focal adhesion formation; positive regulation of attachment of spindle microtubules to kinetochore; regulation of cell migration; sister chromatid cohesion
Reference #:  Q9P258 (UniProtKB)
Alt. Names/Synonyms: DKFZp762N0610; KIAA1470; Protein RCC2; RCC1-like protein TD-60; RCC2; regulator of chromosome condensation 2; TD-60; TD60; Telophase disk protein of 60 kDa
Gene Symbols: RCC2
Molecular weight: 56,085 Da
Basal Isoelectric point: 9.02  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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