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CDKN2C Interacts strongly with CDK6, weakly with CDK4. Inhibits cell growth and proliferation with a correlated dependence on endogenous retinoblastoma protein RB. Heterodimer of p18 with CDK6. Highest levels found in skeletal muscle. Also found in pancreas and heart. Belongs to the CDKN2 cyclin-dependent kinase inhibitor family. Note: This description may include information from UniProtKB.
Protein type: Cell cycle regulation; Inhibitor; Protein kinase, regulatory subunit
Chromosomal Location of Human Ortholog: 1p32.3
Cellular Component: cytoplasm; cytosol; nucleus
Molecular Function: cyclin-dependent protein kinase inhibitor activity; protein binding; protein kinase binding
Biological Process: cell cycle arrest; G1/S transition of mitotic cell cycle; negative regulation of cell growth; negative regulation of cell proliferation; negative regulation of phosphorylation; regulation of cyclin-dependent protein kinase activity
Reference #:  P42773 (UniProtKB)
Alt. Names/Synonyms: CDK6 inhibitor p18; CDKN2C; CDKN6; CDN2C; cyclin-dependent inhibitor; Cyclin-dependent kinase 4 inhibitor C; Cyclin-dependent kinase 6 inhibitor; cyclin-dependent kinase 6 inhibitor p18; cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4); INK4C; p18; p18-INK4c; p18-INK6
Gene Symbols: CDKN2C
Molecular weight: 18,127 Da
Basal Isoelectric point: 6.05  Predict pI for various phosphorylation states
CST Pathways:  G1/S Checkpoint
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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