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Nna1 Metallocarboxypeptidase that mediates deglutamylation of target proteins. Catalyzes the deglutamylation of polyglutamate side chains generated by post-translational polyglutamylation in proteins such as tubulins. Also removes gene-encoded polyglutamates from the carboxy-terminus of target proteins such as MYLK. Acts as a long-chain deglutamylase and specifically shortens long polyglutamate chains, while it is not able to remove the branching point glutamate, a process catalyzed by AGBL5/CCP5. Interacts with MYLK. Belongs to the peptidase M14 family. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: EC 3.4.17.-; Protease
Chromosomal Location of Human Ortholog: 9q21.33
Cellular Component: cytoplasm; cytosol; intracellular membrane-bound organelle; mitochondrion; nucleolus; nucleus
Molecular Function: metallocarboxypeptidase activity; tubulin binding
Biological Process: cerebellar Purkinje cell differentiation; eye photoreceptor cell differentiation; mitochondrion organization and biogenesis; neuromuscular process; olfactory bulb development
Reference #:  Q9UPW5 (UniProtKB)
Alt. Names/Synonyms: AGTPBP1; ATP/GTP binding protein 1; ATP/GTP-binding protein 1; CBPC1; CCP1; Cytosolic carboxypeptidase 1; DKFZp686M20191; KIAA1035; Nervous system nuclear protein induced by axotomy; NNA1
Gene Symbols: AGTPBP1
Molecular weight: 138,448 Da
Basal Isoelectric point: 5.78  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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