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JMJD1B a ubiquitous protein demethylase that specifically demethylates Lys-9 of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May have tumor suppressor activity. Three alternatively spliced isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Demethylase; EC 1.14.11.-; Oxidoreductase
Chromosomal Location of Human Ortholog: 5q31.2
Cellular Component: chromatin; nucleoplasm; nucleus
Molecular Function: chromatin DNA binding; histone demethylase activity; histone demethylase activity (H3-K9 specific)
Biological Process: histone H3-K9 demethylation; regulation of transcription, DNA-dependent
Reference #:  Q7LBC6 (UniProtKB)
Alt. Names/Synonyms: 5qNCA; C5orf7; JHDM2B; JmjC domain-containing histone demethylation protein 2B; JMJD1B; jumonji domain containing 1B; Jumonji domain-containing protein 1B; KDM3B; KIAA1082; lysine (K)-specific demethylase 3B; Lysine-specific demethylase 3B; NET22; Nuclear protein 5qNCA
Gene Symbols: KDM3B
Molecular weight: 191,581 Da
Basal Isoelectric point: 6.78  Predict pI for various phosphorylation states
CST Pathways:  Histone Methylation
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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