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IGF2BP1 a conserved trans-acting factor that can control translation of specific mRNAs in vivo. Contains four K homology (KH) domains and two RNA recognition motifs. It functions by binding to the 5' UTR of the target mRNAs and repressing translation. Target mRNAs include those encoding beta-actin and insulin-like growth factor 2 (IGF2). Tyrosine phosphorylation apparently abolishes translational repression of actin expression by decreasing its binding beta-actin mRNA. May have a role in progression of ovarian cancer. Contains nuclear export signals within the RNA-binding KH2 and KH4 domains. Aberrant expression may interfere with c-myc regulation. Note: This description may include information from UniProtKB.
Protein type: RNA-binding; Translation
Chromosomal Location of Human Ortholog: 17q21.32
Cellular Component: cytoplasm; cytosol; nucleoplasm; ribonucleoprotein complex; stress granule
Molecular Function: mRNA 3'-UTR binding; mRNA 5'-UTR binding; mRNA binding; protein binding; RNA binding; translation regulator activity
Biological Process: negative regulation of translation; regulation of cytokine biosynthetic process; regulation of mRNA stability
Reference #:  Q9NZI8 (UniProtKB)
Alt. Names/Synonyms: Coding region determinant-binding protein; CRD-BP; CRDBP; IF2B1; IGF II mRNA binding protein 1; IGF-II mRNA-binding protein 1; IGF2 mRNA-binding protein 1; IGF2BP1; IMP-1; IMP1; insulin-like growth factor 2 mRNA binding protein 1; Insulin-like growth factor 2 mRNA-binding protein 1; VICKZ family member 1; VICKZ1; ZBP-1; ZBP1; Zip code-binding protein 1; Zipcode-binding protein 1
Gene Symbols: IGF2BP1
Molecular weight: 63,481 Da
Basal Isoelectric point: 9.26  Predict pI for various phosphorylation states
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