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PKACA catalytic subunit of cAMP-dependent protein kinase alpha, an AGC kinase. A number of inactive tetrameric holoenzymes are produced by the combination of homo- or heterodimers of the different regulatory subunits associated with two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Two splice-variant isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: AGC group; EC; Kinase, protein; PKA family; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of Human Ortholog: 19p13.12
Cellular Component: acrosome; centrosome; cytoplasm; cytosol; intercellular bridge; membrane; nuclear speck; nucleoplasm; nucleus; perinuclear region of cytoplasm
Molecular Function: cAMP-dependent protein kinase activity; protein binding; protein kinase binding; protein serine/threonine kinase activity; protein serine/threonine/tyrosine kinase activity; ubiquitin protein ligase binding
Biological Process: activation of protein kinase A; blood coagulation; cytosolic calcium ion homeostasis; G2/M transition of mitotic cell cycle; mRNA processing; peptidyl-serine phosphorylation; regulation of heart rate; regulation of macroautophagy; regulation of osteoblast differentiation; regulation of protein binding; renal water homeostasis; sperm capacitation; stimulatory C-type lectin receptor signaling pathway
Reference #:  P17612 (UniProtKB)
Alt. Names/Synonyms: cAMP-dependent protein kinase; cAMP-dependent protein kinase catalytic subunit alpha; cAMP-dependent protein kinase catalytic subunit alpha, isoform 1; KAPCA; MGC102831; MGC48865; PKA C-alpha; PKACA; PRKACA; protein kinase A; protein kinase A catalytic subunit; protein kinase, cAMP-dependent, catalytic, alpha
Gene Symbols: PRKACA
Molecular weight: 40,590 Da
Basal Isoelectric point: 8.84  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  AMPK Signaling  |  GPCR Signaling to MAPKs  |  Growth And Differentiation Control by MAPKs  |  Hedgehog Signaling  |  Inhibition of Apoptosis  |  Insulin Receptor Signaling  |  Microtubule Dynamics  |  Mitochondrial Control of Apoptosis  |  NF-kB Signaling  |  Parkinson's Disease
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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