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PDK1 an AGC kinase of the PKB family that contains a PH domain. Involved in a wide variety of processes including cell proliferation, differentiation and apoptosis. Autophosphorylation in the activation loop is necessary for activity. Phosphorylates and activates kinases including Akt, PKC isozymes, p70 S6K and RSK. Three alternatively-spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: AGC group; EC; Kinase, protein; Nuclear receptor co-regulator; PKB family; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of Human Ortholog: 16p13.3
Cellular Component: cell projection; cytoplasm; cytoplasmic vesicle; cytosol; focal adhesion; intracellular; membrane; nucleoplasm; perikaryon; plasma membrane; postsynaptic density
Molecular Function: 3-phosphoinositide-dependent protein kinase activity; ATP binding; insulin receptor binding; kinase activity; phospholipase activator activity; phospholipase binding; protein binding; protein kinase binding; protein serine/threonine kinase activity
Biological Process: actin cytoskeleton organization; activation of protein kinase B activity; calcium-mediated signaling; cell migration; cellular response to brain-derived neurotrophic factor stimulus; cellular response to epidermal growth factor stimulus; cellular response to insulin stimulus; epidermal growth factor receptor signaling pathway; Fc-epsilon receptor signaling pathway; focal adhesion assembly; hyperosmotic response; negative regulation of cardiac muscle cell apoptotic process; negative regulation of neuron apoptosis; negative regulation of protein kinase activity; negative regulation of toll-like receptor signaling pathway; negative regulation of transforming growth factor beta receptor signaling pathway; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; platelet activation; positive regulation of angiogenesis; positive regulation of blood vessel endothelial cell migration; positive regulation of phospholipase activity; positive regulation of release of sequestered calcium ion into cytosol; positive regulation of vascular endothelial cell proliferation; protein amino acid phosphorylation; protein autophosphorylation; regulation of I-kappaB kinase/NF-kappaB cascade; regulation of mast cell degranulation; regulation of transcription, DNA-templated; stimulatory C-type lectin receptor signaling pathway; T cell costimulation; T cell receptor signaling pathway; transcription, DNA-dependent; type B pancreatic cell development
Reference #:  O15530 (UniProtKB)
Alt. Names/Synonyms: 3-phosphoinositide dependent protein kinase-1; 3-phosphoinositide-dependent protein kinase 1; hPDK1; MGC20087; MGC35290; PDK1; PDPK1; PkB kinase like gene 1; PkB-like 1; PRO0461; protein kinase
Gene Symbols: PDPK1
Molecular weight: 63,152 Da
Basal Isoelectric point: 6.95  Predict pI for various phosphorylation states
CST Pathways:  Inhibition of Apoptosis  |  Insulin Receptor Signaling  |  mTOR Signaling  |  NF-kB Signaling  |  PI3K/Akt Signaling  |  Protein Kinase C Signaling  |  T Cell Receptor Signaling  |  Translation: eIF4E and p70S6K
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