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PAK3 a protein kinase of the STE20 family that regulates synapse formation and plasticity in the hippocampus. May be necessary for dendritic development and for the rapid cytoskeletal reorganization in dendritic spines associated with synaptic plasticity. Forms an activated complex with GTP-bound P21, CDC2 and RAC1 proteins. Missense and truncation mutations linked to nonsyndromic mental retardation type 30 (MRX30). Two alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Kinase, protein; PAKA subfamily; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor); STE group; STE20 family
Chromosomal Location of Human Ortholog: Xq23
Cellular Component: cytoplasm; cytosol; plasma membrane
Molecular Function: MAP kinase kinase activity; protein binding; protein serine/threonine kinase activity; Rac GTPase binding
Biological Process: axonogenesis; cell migration; dendrite development; ephrin receptor signaling pathway; regulation of actin filament polymerization; regulation of apoptosis; regulation of axonogenesis; regulation of mitotic cell cycle; Rho protein signal transduction; stimulatory C-type lectin receptor signaling pathway; stress-activated protein kinase signaling pathway; synapse organization and biogenesis; T cell costimulation; T cell receptor signaling pathway
Disease: Mental Retardation, X-linked 30
Reference #:  O75914 (UniProtKB)
Alt. Names/Synonyms: Beta-PAK; bPAK; CDKN1A; hPAK3; MRX30; MRX47; Oligophrenin-3; OPHN3; p21 (CDKN1A)-activated kinase 3; p21 protein (Cdc42/Rac)-activated kinase 3; p21-activated kinase 3; PAK-3; PAK3; PAK3beta; Serine/threonine-protein kinase PAK 3
Gene Symbols: PAK3
Molecular weight: 62,310 Da
Basal Isoelectric point: 5.33  Predict pI for various phosphorylation states
CST Pathways:  Growth And Differentiation Control by MAPKs  |  Microtubule Dynamics  |  TGF-ß Signaling
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