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DBC-1 Core component of the DBIRD complex, a multiprotein complex that acts at the interface between core mRNP particles and RNA polymerase II (RNAPII) and integrates transcript elongation with the regulation of alternative splicing: the DBIRD complex affects local transcript elongation rates and alternative splicing of a large set of exons embedded in (A + T)-rich DNA regions. Inhibits SIRT1 deacetylase activity leading to increasing levels of p53/TP53 acetylation and p53-mediated apoptosis. Inhibits SUV39H1 methyltransferase activity. Component of the DBIRD complex. Interacts with ZNF326/ZIRD; the interaction is direct. Interacts (via N-terminus) with SIRT1. Interacts (via N-terminus) with SUV39H1; this interaction abolishes the interaction with SIRT1. Expressed ubiquitously in normal tissues. Expressed in 84 to 100% of neoplastic breast, lung, and colon tissues. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Apoptosis; Mitochondrial; Nuclear receptor co-regulator; RNA-binding; Tumor suppressor
Chromosomal Location of Human Ortholog: 8p21.3
Cellular Component: cytoplasm; mitochondrial matrix; nuclear chromatin; nucleoplasm; nucleus; spliceosome
Molecular Function: enzyme binding; enzyme inhibitor activity; protein binding; RNA binding
Biological Process: mitochondrial fragmentation during apoptosis; negative regulation of catalytic activity; negative regulation of cell growth; negative regulation of proteasomal ubiquitin-dependent protein catabolic process; negative regulation of transcription, DNA-dependent; positive regulation of apoptosis; regulation of circadian rhythm; regulation of protein stability; regulation of RNA elongation; response to UV; RNA splicing
Reference #:  Q8N163 (UniProtKB)
Alt. Names/Synonyms: cell cycle and apoptosis regulator 2; DBC-1; DBC.1; DBC1; deleted in breast cancer 1; Deleted in breast cancer gene 1 protein; K1967; KIAA1967; NET35; p30 DBC; p30 DBC protein
Gene Symbols: CCAR2
Molecular weight: 102,902 Da
Basal Isoelectric point: 5.14  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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