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RAC3 Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses, such as cell spreading and the formation of actin-based protusions including lamellipodia and membrane ruffles. Interacts with the GEF protein DOCK7, which promotes the exchange between GDP and GTP, and therefore activates it. Interacts with C1D. Expression down-regulated in quiescent fibroblasts and clearly induced by serum stimulation. Highest levels in brain, also detected in heart, placenta and pancreas. Belongs to the small GTPase superfamily. Rho family. Note: This description may include information from UniProtKB.
Protein type: G protein; G protein, monomeric; G protein, monomeric, Rho; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 17q25.3
Cellular Component: cell soma; cytosol; endomembrane system; filamentous actin; growth cone; neuron projection; perinuclear region of cytoplasm; plasma membrane
Molecular Function: calcium-dependent protein binding; GTPase activity; protein binding
Biological Process: actin cytoskeleton organization and biogenesis; cell projection biogenesis; positive regulation of cell adhesion mediated by integrin; regulation of small GTPase mediated signal transduction
Reference #:  P60763 (UniProtKB)
Alt. Names/Synonyms: p21-Rac3; RAC3; Ras-related C3 botulinum toxin substrate 3; ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3); rho family, small GTP binding protein Rac3
Gene Symbols: RAC3
Molecular weight: 21,379 Da
Basal Isoelectric point: 8.43  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  Adherens Junction Dynamics  |  B Cell Receptor Signaling  |  Growth And Differentiation Control by MAPKs  |  SAPK/JNK Signaling Cascades  |  T Cell Receptor Signaling  |  TGF-ß Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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