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EDC4 a protein required for the 5' a?? 3' pathway of mRNA decapping and degradation-based post-transcriptional gene silencing. The proteins involved in 5' a?? 3' mRNA decay include DCP2, DCP1A, EDC3, EDC4 and DDX6, and are concentrated in cytoplasmic structures called mRNA "processing bodies" (P-bodies). Shortening of the 3'-poly(A) tail and removal of PABP precedes cleavage of the 5'-mRNA cap by a complex containing decapping enzymes 1A and 2 (DCP1A/DCP2). EDC4 enhances the catalytic activity of DCP2 in vitro. Shown to be required for silencing by miRNAs in Drosophila melanogaster. Two alternatively spliced human isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: RNA processing
Chromosomal Location of Human Ortholog: 16q22.1
Cellular Component: cytoplasm; cytosol; membrane; nucleoplasm; nucleus
Molecular Function: protein binding
Biological Process: deadenylation-independent decapping
Reference #:  Q6P2E9 (UniProtKB)
Alt. Names/Synonyms: Autoantigen Ge-1; Autoantigen RCD-8; EDC4; enhancer of mRNA decapping 4; Enhancer of mRNA-decapping protein 4; Ge-1; HEDLS; Human enhancer of decapping large subunit; RCD-8
Gene Symbols: EDC4
Molecular weight: 151,661 Da
Basal Isoelectric point: 5.55  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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