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LYN a tyrosine kinase of the Src family that plays a role in B cell antigen-receptor signaling. Note: This description may include information from UniProtKB.
Protein type: EC; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor); Src family; TK group
Chromosomal Location of Human Ortholog: 8q12.1
Cellular Component: cell-cell adherens junction; cytoplasm; cytosol; extracellular exosome; extrinsic component of cytoplasmic side of plasma membrane; Golgi apparatus; integrin alpha2-beta1 complex; intracellular membrane-bound organelle; mast cell granule; membrane raft; mitochondrial crista; mitochondrial intermembrane space; nucleus; perinuclear region of cytoplasm; plasma membrane; postsynaptic density
Molecular Function: ATP binding; ephrin receptor binding; gamma-tubulin binding; glycosphingolipid binding; integrin binding; ion channel binding; kinase activity; non-membrane spanning protein tyrosine kinase activity; phosphoprotein binding; phosphorylation-dependent protein binding; platelet-derived growth factor receptor binding; protein binding; protein tyrosine kinase activity; receptor binding; SH3 domain binding; signal transducer, downstream of receptor, with protein tyrosine kinase activity; ubiquitin protein ligase binding
Biological Process: adaptive immune response; B cell homeostasis; B cell receptor signaling pathway; blood coagulation; cellular response to DNA damage stimulus; cellular response to extracellular stimulus; cellular response to heat; cellular response to retinoic acid; central nervous system development; cytokine secretion; ephrin receptor signaling pathway; erythrocyte differentiation; Fc receptor mediated inhibitory signaling pathway; Fc receptor mediated stimulatory signaling pathway; Fc-epsilon receptor signaling pathway; Fc-gamma receptor signaling pathway involved in phagocytosis; histamine secretion by mast cell; immune response-regulating cell surface receptor signaling pathway; inflammatory response; innate immune response; leukocyte migration; lipopolysaccharide-mediated signaling pathway; negative regulation of B cell proliferation; negative regulation of cell proliferation; negative regulation of ERK1 and ERK2 cascade; negative regulation of immune response; negative regulation of intracellular signal transduction; negative regulation of MAP kinase activity; negative regulation of myeloid leukocyte differentiation; negative regulation of protein phosphorylation; negative regulation of toll-like receptor 2 signaling pathway; negative regulation of toll-like receptor 4 signaling pathway; neuron projection development; oligodendrocyte development; peptidyl-tyrosine autophosphorylation; peptidyl-tyrosine phosphorylation; platelet activation; platelet degranulation; positive regulation of B cell receptor signaling pathway; positive regulation of cell migration; positive regulation of cell proliferation; positive regulation of cellular component movement; positive regulation of dendritic cell apoptotic process; positive regulation of neuron projection development; positive regulation of oligodendrocyte progenitor proliferation; positive regulation of phosphatidylinositol 3-kinase activity; positive regulation of protein phosphorylation; positive regulation of stress-activated protein kinase signaling cascade; positive regulation of tyrosine phosphorylation of STAT protein; protein amino acid phosphorylation; protein autophosphorylation; regulation of B cell apoptotic process; regulation of B cell receptor signaling pathway; regulation of cell adhesion mediated by integrin; regulation of cytokine production; regulation of cytokine secretion; regulation of ERK1 and ERK2 cascade; regulation of erythrocyte differentiation; regulation of inflammatory response; regulation of mast cell activation; regulation of mast cell degranulation; regulation of monocyte chemotaxis; regulation of platelet aggregation; regulation of protein amino acid phosphorylation; regulation of release of sequestered calcium ion into cytosol; response to amino acid; response to axon injury; response to carbohydrate stimulus; response to drug; response to hormone; response to insulin stimulus; response to organic cyclic compound; response to sterol depletion; response to toxin; signal transduction; stimulatory C-type lectin receptor signaling pathway; T cell costimulation; tolerance induction to self antigen; transmembrane receptor protein tyrosine kinase signaling pathway; viral process
Reference #:  P07948 (UniProtKB)
Alt. Names/Synonyms: FLJ26625; JTK8; LYN; Tyrosine-protein kinase Lyn; v-yes-1 Yamaguchi sarcoma viral related oncogene homolog; Yamaguchi sarcoma viral (v-yes-1) related oncogene homolog
Gene Symbols: LYN
Molecular weight: 58,574 Da
Basal Isoelectric point: 6.7  Predict pI for various phosphorylation states
CST Pathways:  B Cell Receptor Signaling  |  GPCR Signaling to MAPKs  |  PI3K/Akt Signaling  |  Tyrosine Kinases & Substrates
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