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NOT3 The CCR4-NOT complex functions as general transcription regulation complex. Belongs to the CNOT2/3/5 family. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Chromosomal Location of Human Ortholog: 19q13.42
Cellular Component: CCR4-NOT complex; cytosol
Molecular Function: protein binding
Biological Process: DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; mRNA catabolic process, deadenylation-dependent decay; negative regulation of translation; poly(A) tail shortening
Reference #:  O75175 (UniProtKB)
Alt. Names/Synonyms: CCR4-associated factor 3; CCR4-NOT transcription complex subunit 3; CCR4-NOT transcription complex, subunit 3; CNOT3; KIAA0691; LENG2; Leukocyte receptor cluster member 2; NOT3; NOT3 (negative regulator of transcription 3, yeast) homolog; NOT3H
Gene Symbols: CNOT3
Molecular weight: 81,872 Da
Basal Isoelectric point: 5.82  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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