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VEGFR2 a receptor tyrosine kinase of the VEGFR family. High affinity receptor for VEGF and VEGF-C. Ligand binding induces autophosphorylation and activation. Activated receptor recruits proteins including Shc, GRB2, PI3K, Nck, SHP-1 and SHP-2. Plays a key role in vascular development and regulation of vascular permeability. Note: This description may include information from UniProtKB.
Protein type: EC; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor); TK group; VEGFR family
Chromosomal Location of Human Ortholog: 4q12
Cellular Component: cell junction; early endosome; endoplasmic reticulum; endosome; extracellular region; Golgi apparatus; integral component of plasma membrane; membrane raft; nucleus; plasma membrane
Molecular Function: ATP binding; growth factor binding; Hsp90 protein binding; identical protein binding; integrin binding; protein binding; protein tyrosine kinase activity; signal transducer, downstream of receptor, with protein tyrosine kinase activity; transmembrane receptor protein tyrosine kinase activity; vascular endothelial growth factor-activated receptor activity
Biological Process: angiogenesis; cell migration during sprouting angiogenesis; cellular response to hydrogen sulfide; embryonic hemopoiesis; endothelium development; ERK1 and ERK2 cascade; extracellular matrix organization; negative regulation of apoptosis; negative regulation of endothelial cell apoptotic process; negative regulation of gene expression; peptidyl-tyrosine autophosphorylation; peptidyl-tyrosine phosphorylation; positive regulation of angiogenesis; positive regulation of blood vessel endothelial cell migration; positive regulation of cell migration; positive regulation of cell proliferation; positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway; positive regulation of endothelial cell migration; positive regulation of endothelial cell proliferation; positive regulation of ERK1 and ERK2 cascade; positive regulation of focal adhesion assembly; positive regulation of macroautophagy; positive regulation of MAPK cascade; positive regulation of mitochondrial depolarization; positive regulation of mitochondrial fission; positive regulation of nitric-oxide synthase biosynthetic process; positive regulation of phosphoinositide 3-kinase cascade; positive regulation of positive chemotaxis; positive regulation of protein phosphorylation; positive regulation of vasculogenesis; protein autophosphorylation; protein kinase B signaling; regulation of cell shape; transmembrane receptor protein tyrosine kinase signaling pathway; vascular endothelial growth factor receptor signaling pathway; vasculogenesis; viral process
Disease: Hemangioma, Capillary Infantile
Reference #:  P35968 (UniProtKB)
Alt. Names/Synonyms: CD309; Fetal liver kinase 1; fetal liver kinase-1; FLK-1; FLK1; KDR; Kinase insert domain receptor; kinase insert domain receptor (a type III receptor tyrosine kinase); Protein-tyrosine kinase receptor flk-1; soluble VEGFR2; tyrosine kinase growth factor receptor; Vascular endothelial growth factor receptor 2; VEGFR; VEGFR-2; VEGFR2; VGFR2
Gene Symbols: KDR
Molecular weight: 151,527 Da
Basal Isoelectric point: 5.6  Predict pI for various phosphorylation states
CST Pathways:  Angiogenesis  |  Tyrosine Kinases & Substrates
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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