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Protein Page:

PPM1D a magnesium-dependent Ser/Thr phosphatase. A p53-induced phosphatase that interacts with the nuclear isoform of uracil DNA glycosylase, UNG2, and suppresses base excision repair. Might contribute to growth inhibitory pathways activated in response to DNA damage in a p53-dependent manner. Note: This description may include information from UniProtKB.
Protein type: Cell cycle regulation; EC; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Protein phosphatase, Ser/Thr (non-receptor)
Chromosomal Location of Human Ortholog: 17q23.2
Cellular Component: nucleus
Molecular Function: mitogen-activated protein kinase binding; protein binding; protein serine/threonine phosphatase activity
Biological Process: negative regulation of cell proliferation; protein amino acid dephosphorylation; response to radiation
Disease: Breast Cancer; Intellectual Developmental Disorder With Gastrointestinal Difficulties And High Pain Threshold
Reference #:  O15297 (UniProtKB)
Alt. Names/Synonyms: p53-induced protein phosphatase 1; PP2C-delta; PPM1D; Protein phosphatase 1D; protein phosphatase 1D magnesium-dependent, delta isoform; protein phosphatase 2C delta isoform; Protein phosphatase 2C isoform delta; Protein phosphatase magnesium-dependent 1 delta; protein phosphatase Wip1; protein phosphatase, Mg2+/Mn2+ dependent, 1D; wild-type p53-induced phosphatase 1; WIP1
Gene Symbols: PPM1D
Molecular weight: 66,675 Da
Basal Isoelectric point: 9.14  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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