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USP9X Deubiquitinase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. May therefore play an important role regulatory role at the level of protein turnover by preventing degradation of proteins through the removal of conjugated ubiquitin. Essential component of TGF-beta/BMP signaling cascade. Regulates chromosome alignment and segregation in mitosis by regulating the localization of BIRC5/survivin to mitotic centromeres. Specifically hydrolyzes both 'Lys-29'- and 'Lys-33'-linked polyubiquitins chains. Specifically deubiquitinates monoubiquitinated SMAD4, opposing the activity of E3 ubiquitin-protein ligase TRIM33. Interacts with SMAD4, MARK4, NUAK1 and BIRC5/survivin. Widely expressed in embryonic and adult tissues. Belongs to the peptidase C19 family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: EC; Protease; Ubiquitin conjugating system; Ubiquitin-specific protease
Chromosomal Location of Human Ortholog: Xp11.4
Cellular Component: cytoplasm; cytosol; growth cone; membrane
Molecular Function: co-SMAD binding; cysteine-type endopeptidase activity; cysteine-type peptidase activity; protein binding; thiol-dependent ubiquitinyl hydrolase activity
Biological Process: axon extension; BMP signaling pathway; cell cycle; cell division; cellular protein metabolic process; chromosome segregation; female gamete generation; negative regulation of transcription from RNA polymerase II promoter; neuron migration; protein deubiquitination; protein ubiquitination; transforming growth factor beta receptor signaling pathway; ubiquitin-dependent protein catabolic process
Disease: Mental Retardation, X-linked 99; Mental Retardation, X-linked 99, Syndromic, Female-restricted
Reference #:  Q93008 (UniProtKB)
Alt. Names/Synonyms: Deubiquitinating enzyme FAF-X; DFFRX; Drosophila fat facets related, X-linked; FAF; FAM; Fat facets in mammals; fat facets protein related, X-linked; Fat facets protein-related, X-linked; hFAM; Probable ubiquitin carboxyl-terminal hydrolase FAF-X; ubiquitin specific peptidase 9, X-linked; ubiquitin specific protease 9, X chromosome (fat facets-like Drosophila); Ubiquitin thioesterase FAF-X; ubiquitin thiolesterase FAF-X; ubiquitin-specific processing protease FAF-X; Ubiquitin-specific protease 9, X chromosome; Ubiquitin-specific-processing protease FAF-X; USP9; USP9X
Gene Symbols: USP9X
Molecular weight: 292,280 Da
Basal Isoelectric point: 5.52  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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