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PACT a double strand RNA binding protein (dsRBP). Interacts with TRBP and Dicer to stimulate the cleavage of double-stranded or short hairpin RNA to siRNA. Appears to have a pro-apoptotic function that may be suppressed in the presence of growth factor. Activates the interferon-induced protein kinase PKR. Three alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Activator; RNA processing; RNA-binding
Chromosomal Location of Human Ortholog: 2q31.2
Cellular Component: cytoplasm; cytosol; membrane; nucleoplasm
Molecular Function: double-stranded RNA binding; enzyme binding; identical protein binding; protein binding; protein homodimerization activity; RNA binding
Biological Process: immune response; miRNA-mediated gene silencing, production of miRNAs; negative regulation of cell proliferation; pre-microRNA processing; protein stabilization; response to virus; RNA interference, production of siRNA
Disease: Dystonia 16
Reference #:  O75569 (UniProtKB)
Alt. Names/Synonyms: DYT16; HSD14; Interferon-inducible double stranded RNA-dependent protein kinase activator A; PACT; PKR-associated protein X; PKR-associating protein X; PRKRA; Protein activator of the interferon-induced protein kinase; protein kinase, interferon-inducible double stranded RNA dependent activator; Protein kinase, interferon-inducible double stranded RNA-dependent activator; RAX
Gene Symbols: PRKRA
Molecular weight: 34,404 Da
Basal Isoelectric point: 8.68  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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