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NSF required for intracellular membrane fusion and vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seem to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin. Functions as a SNAP receptor (SNARE) chaperone which binds, through soluble NSF attachment proteins (SNAPs), to SNARE complexes and utilizes the energy of ATP hydrolysis to disassemble them thus facilitating SNARE recycling. While this is a major function of NSF, it does seem to interact with other proteins, such as the AMPA receptor subunit, GluR2, and beta2-AR and is thought to affect their trafficking patterns. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Autophagy; EC; Protease; Vesicle
Chromosomal Location of Human Ortholog: 17q21.31
Cellular Component: cytosol; dendritic shaft; Golgi stack; lysosomal membrane; plasma membrane; postsynaptic density
Molecular Function: ATPase activity; ionotropic glutamate receptor binding; PDZ domain binding; protein binding; protein complex binding; protein kinase binding; Rab GTPase binding; SNARE binding; syntaxin-1 binding
Biological Process: COPII coating of Golgi vesicle; ER to Golgi vesicle-mediated transport; exocytosis; intracellular protein transport; plasma membrane fusion; positive regulation of protein catabolic process; positive regulation of receptor recycling; regulation of exocytosis; retrograde vesicle-mediated transport, Golgi to ER; vesicle-mediated transport
Reference #:  P46459 (UniProtKB)
Alt. Names/Synonyms: N-ethylmaleimide-sensitive factor; N-ethylmaleimide-sensitive factor-like protein; N-ethylmaleimide-sensitive fusion protein; NEM-sensitive fusion protein; NSF; SKD2; Vesicle-fusing ATPase; Vesicular-fusion protein NSF
Gene Symbols: NSF
Molecular weight: 82,594 Da
Basal Isoelectric point: 6.52  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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