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ILK a tyrosine kinase-like kinase of the MLK family. Couples integrins and growth factors to downstream pathways involved in cell survival, cell cycle control, cell-cell adhesion and cell motility. Functions as a scaffold bridging the extra-cellular matrix and growth factor receptors to the actin cytoskeleton through interactions with the ILK-PINCH complex. This complex, which includes integrin, PINCH (which links ILK to receptor tyrosine kinases via Nck2), PARVA and affixin, is considered to be one of the convergence points of integrin- and growth factor-signaling pathways. May be implicated in mediating cell architecture, adhesion to integrin substrates and anchorage-dependent growth in epithelial cells. Stimulated downstream of PI3 kinase. Increased expression is correlated with progression of several tumor types, including breast, prostate, and colon carcinomas. Overexpression drives anchorage-independent growth and faster cell cycle. Note: This description may include information from UniProtKB.
Protein type: EC; ILK subfamily; Kinase, protein; MLK family; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL; TKL group
Chromosomal Location of Human Ortholog: 11p15.4
Cellular Component: cell junction; cytoplasm; cytosol; focal adhesion; membrane; nucleoplasm; stress fiber
Molecular Function: protein binding; protein kinase binding; protein serine/threonine kinase activity; signal transducer activity
Biological Process: cell-matrix adhesion; integrin-mediated signaling pathway; MAPKKK cascade; multicellular organismal development; positive regulation of phosphorylation; positive regulation of transcription, DNA-dependent; protein amino acid phosphorylation; tumor necrosis factor-mediated signaling pathway
Reference #:  Q13418 (UniProtKB)
Alt. Names/Synonyms: 59 kDa serine/threonine-protein kinase; DKFZp686F1765; ILK; ILK-1; ILK-2; ILK1; ILK2; integrin-linked kinase; Integrin-linked protein kinase; P59; p59ILK
Gene Symbols: ILK
Molecular weight: 51,419 Da
Basal Isoelectric point: 8.3  Predict pI for various phosphorylation states
CST Pathways:  PI3K/Akt Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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